Bax^tm1Sjk
Targeted Allele Detail

Summary

• Symbol: Bax^tm1Sjk
• Name: BCL2-associated X protein; targeted mutation 1, Stanley J Korsmeyer
• MGI ID: MGI:1857429
• Synonyms: Bax^-, Bax1
• Gene: Bax Location: Chr7:45111121-45116322 bp, - strand Genetic Position: Chr7, 29.32 cM, cytoband B5
• Alliance: Bax^tm1Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29253
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 2 through 4 and part of exon 5, which encode sequences that correspond to the two BCL2 homology domains BH1 and BH2. Immunoblots did not detect the endcoded protein in tissue lysates derived from homozygous mice. (J:29253)

Expression

In Mice Carrying this Mutation:	108 assay results 8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bax^tm1Sjk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bax Mutation: 24 strains or lines available

References

• Original: J:29253 Knudson CM, et al., Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science. 1995 Oct 6;270(5233):96-9
• All: 377 reference(s)