Bcl2^tm1Mpin
Targeted Allele Detail

Summary

• Symbol: Bcl2^tm1Mpin
• Name: B cell leukemia/lymphoma 2; targeted mutation 1, Max-Planck-Institute for Neurobiology
• MGI ID: MGI:1857430
• Synonyms: bcl-2 -
• Gene: Bcl2 Location: Chr1:106465908-106642004 bp, - strand Genetic Position: Chr1, 49.76 cM
• Alliance: Bcl2^tm1Mpin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34326
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a lacZ gene and neomycin selection cassette. Western blot analysis on hippocampal lysates from homozygous mice demonstrated that no stable Bcl2 protein was made from this allele. A beta-galactosidase protein was produced from this allele under the control of the endogenous promoter. (J:34326, J:86581)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl2 Mutation: 41 strains or lines available

References

• Original: J:34326 Michaelidis TM, et al., Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron. 1996 Jul;17(1):75-89
• All: 11 reference(s)