Col3a1^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Col3a1^tm1Jae
• Name: collagen, type III, alpha 1; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:1857431
• Gene: Col3a1 Location: Chr1:45350698-45388866 bp, + strand Genetic Position: Chr1, 23.67 cM
• Alliance: Col3a1^tm1Jae page

Col3a1^tm1Jae/Col3a1^tm1Jae mouse with skin lesion

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39273
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing the promoter region and first exon of the gene. Protein analysis of isolated tail and skin collagens from homozygous mice demonstrated that no stable protein was produced from this allele. (J:39273)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col3a1 Mutation: 85 strains or lines available

References

• Original: J:39273 Liu X, et al., Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1852-6 SS 18 /C?
• All: 9 reference(s)