Emx1^tm1Jlr
Targeted Allele Detail

Summary

• Symbol: Emx1^tm1Jlr
• Name: empty spiracles homeobox 1; targeted mutation 1, John Rubenstein
• MGI ID: MGI:1857433
• Synonyms: Emx-1-, Emx1^null
• Gene: Emx1 Location: Chr6:85164913-85181445 bp, + strand Genetic Position: Chr6, 37.21 cM
• Alliance: Emx1^tm1Jlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35060
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a PGK-neomycin resistance cassette replaced exon 1 and part of intron 1 of the Emx1 gene. Northern analysis of E14.5 embryos did not detect Emx1 transcript in homozygous mutant mice. The authors predict that the mutant allele would produce a truncated protein that lacks the N-terminus. (J:35060)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Emx1 Mutation: 34 strains or lines available

References

• Original: J:35060 Qiu M, et al., Mutation of the Emx-1 homeobox gene disrupts the corpus callosum. Dev Biol. 1996 Aug 25;178(1):174-8
• All: 7 reference(s)