Fshb^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Fshb^tm1Zuk
• Name: follicle stimulating hormone beta; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:1857434
• Synonyms: FSHbeta^-, FSHbetaKO, fshb^m1
• Gene: Fshb Location: Chr2:106886485-106890001 bp, - strand Genetic Position: Chr2, 56.02 cM
• Alliance: Fshb^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38099
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An HPRT minigene replaced a genomic fragment containing exons 1, 2 and part of 3. Northern blot analysis on RNA derived from pituitary of homozygous mice demonstrated that no detectable transcript was produced from thia allele. Radioimmunoasays on serum from homozygous mice confirmed that no functional protein was expressed from this allele. (J:38099)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fshb^tm1Zuk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fshb Mutation: 12 strains or lines available

References

• Original: J:38099 Kumar TR, et al., Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet. 1997 Feb;15(2):201-4
• All: 31 reference(s)