Ggta1^tm1Jbl
Targeted Allele Detail

Summary

• Symbol: Ggta1^tm1Jbl
• Name: glycoprotein galactosyltransferase alpha 1, 3; targeted mutation 1, John B Lowe
• MGI ID: MGI:1857435
• Synonyms: alpha1,3GT-, alpha1,3GT KO, Gal KO, GalT^-, Gt⁰
• Gene: Ggta1 Location: Chr2:35290191-35353243 bp, - strand Genetic Position: Chr2, 23.6 cM
• Alliance: Ggta1^tm1Jbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28755
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette was inserted into the catalytic domain in exon 9 of the Ggta1 gene. The disruption deleted 500 bp of coding sequence. Immunohistochemical studies did not detect terminal alpha galactosides in tissues of homozygous mutant mice. (J:28755)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ggta1 Mutation: 81 strains or lines available

References

• Original: J:28755 Thall AD, et al., Oocyte Gal alpha 1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse. J Biol Chem. 1995 Sep 15;270(37):21437-40
• All: 33 reference(s)