Gria2^tm1Rod
Targeted Allele Detail

Summary

• Symbol: Gria2^tm1Rod
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1, John Roder
• MGI ID: MGI:1857436
• Synonyms: GluA2, GluR2-
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm1Rod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64275
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 11 of the gene, which encodes the pore loop and transmembrane region, TM1. Western blots of brain plasma membranes from homozygous mutant mice showed no detectable protein for the targeted gene. (J:64275)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 79 strains or lines available

References

• Original: J:64275 Jia Z, et al., Enhanced LTP in mice deficient in the AMPA receptor GluR2. Neuron. 1996 Nov;17(5):945-56
• All: 26 reference(s)