Grm5^tm1Rod
Targeted Allele Detail

Summary

• Symbol: Grm5^tm1Rod
• Name: glutamate receptor, metabotropic 5; targeted mutation 1, John C Roder
• MGI ID: MGI:1857437
• Synonyms: Gprc1e^tm1Rod, mGluR5-
• Gene: Grm5 Location: Chr7:87233376-87784115 bp, + strand Genetic Position: Chr7, 49.01 cM
• Alliance: Grm5^tm1Rod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41096
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to delete a 0.4 kb fragment containing part of exon 1 and a part of intron 1, with a neomycin resistance cassette. Western blot failed to detect protein in mutants. (J:51151)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Grm5 Mutation: 78 strains or lines available

References

• Original: J:41096 Lu YM, et al., Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci. 1997 Jul 1;17(13):5196-205
• All: 64 reference(s)