Htr2c^tm1Jul
Targeted Allele Detail

Summary

• Symbol: Htr2c^tm1Jul
• Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1, David Julius
• MGI ID: MGI:1857439
• Synonyms: 5-HT2cR-deficient
• Gene: Htr2c Location: ChrX:145745509-145980273 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband D-F4
• Alliance: Htr2c^tm1Jul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24339
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Insertion of a nonsense mutation into exon 5 of the gene resulted in the introduction of a stop codon within the fifth putative transmembrane segment of the receptor and in the elimination of the carboxy-terminal half of the protein. (J:24339)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr2c Mutation: 13 strains or lines available

Notes

ES cell line = D3 (129S2/SvPas) or J1 (129S4/SvJae).

References

• Original: J:24339 Tecott LH, et al., Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors [see comments]. Nature. 1995 Apr 6;374(6522):542-6
• All: 39 reference(s)