Il12rb1^tm1Jm
Targeted Allele Detail

Summary

• Symbol: Il12rb1^tm1Jm
• Name: interleukin 12 receptor, beta 1; targeted mutation 1, Jeanne Magram
• MGI ID: MGI:1857440
• Synonyms: IL-12Rbeta1^-, IL-12Rbeta1KO
• Gene: Il12rb1 Location: Chr8:71261093-71274068 bp, + strand Genetic Position: Chr8, 34.21 cM
• Alliance: Il12rb1^tm1Jm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42105
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1 to 3 of the gene, deleting the ATG translation initiation codon and causing a frame-shift in the translation reading frame. (J:42105)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il12rb1 Mutation: 33 strains or lines available

References

• Original: J:42105 Wu C, et al., Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor. J Immunol. 1997 Aug 15;159(4):1658-65
• All: 39 reference(s)