Il1r1^tm1Roml
Targeted Allele Detail

Summary

• Symbol: Il1r1^tm1Roml
• Name: interleukin 1 receptor, type I; targeted mutation 1, Mark A Labow
• MGI ID: MGI:1857441
• Synonyms: IL-1RI^-, IL-1RI-deficient, IL-1rKO
• Gene: Il1r1 Location: Chr1:40264240-40356417 bp, + strand Genetic Position: Chr1, 18.81 cM
• Alliance: Il1r1^tm1Roml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42373
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene cassette replaced an ~1 kb region of the DNA that includes one exon of the gene, which encodes the signal peptide and contains a possible ATG initiation codon. (J:42373)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il1r1 Mutation: 39 strains or lines available

References

• Original: J:42373 Labow M, et al., Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J Immunol. 1997 Sep 1;159(5):2452-61
• All: 131 reference(s)