Kcne1^tm1Sfh
Targeted Allele Detail

Summary

• Symbol: Kcne1^tm1Sfh
• Name: potassium voltage-gated channel, Isk-related subfamily, member 1; targeted mutation 1, Stephen F Heinemann
• MGI ID: MGI:1857442
• Synonyms: isk-, KCNE1-
• Gene: Kcne1 Location: Chr16:92142889-92156356 bp, - strand Genetic Position: Chr16, 53.57 cM
• Alliance: Kcne1^tm1Sfh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37461
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced the entire coding region of the gene. (J:37461)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kcne1 Mutation: 13 strains or lines available

References

• Original: J:37461 Vetter DE, et al., Inner ear defects induced by null mutation of the isk gene. Neuron. 1996 Dec;17(6):1251-64
• All: 19 reference(s)