L1cam^tm1Sor
Targeted Allele Detail

Summary

• Symbol: L1cam^tm1Sor
• Name: L1 cell adhesion molecule; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:1857443
• Synonyms: L1^-
• Gene: L1cam Location: ChrX:72897384-72924843 bp, - strand Genetic Position: ChrX, 37.43 cM, cytoband A6-B
• Alliance: L1cam^tm1Sor page

Cerebellar abnormalities in L1cam^tm1Sor/Y Nrcam^tm1Gmt/Nrcam^tm1Gmt mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45013
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the exons encoding the sixth immunoglobulin-like domain of the protein. Immunoblots of lysates of adult brains from homozygous mutant mice showed an absence of normal protein. (J:45013)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any L1cam Mutation: 12 strains or lines available

References

• Original: J:45013 Cohen NR, et al., Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. Curr Biol. 1998 Jan 1;8(1):26-33
• All: 15 reference(s)