Plp1^tm1Kan
Targeted Allele Detail

Summary

• Symbol: Plp1^tm1Kan
• Name: proteolipid protein (myelin) 1; targeted mutation 1, Klaus-Armin Nave
• MGI ID: MGI:1857446
• Synonyms: Plp-, PLP/DM20 null, PLP-null
• Gene: Plp1 Location: ChrX:135723420-135740482 bp, + strand Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
• Alliance: Plp1^tm1Kan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38856
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette introduced by homologous recombination replaced the 3' part of exon 1,including the translation start codon and a 2.5 kb fragment of the first intron of Plp ("PLP/DM20 gene"). Western blot analysis showed absence of both PLP and DM20 proteolipids proteins in hemizygous mutant mice. (J:38856)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plp1 Mutation: 18 strains or lines available

References

• Original: J:38856 Klugmann M, et al., Assembly of CNS myelin in the absence of proteolipid protein. Neuron. 1997 Jan;18(1):59-70
• All: 38 reference(s)