Rbl1^tm1Tyj
Targeted Allele Detail

Summary

• Symbol: Rbl1^tm1Tyj
• Name: RB transcriptional corepressor like 1; targeted mutation 1, Tyler Jacks
• MGI ID: MGI:1857448
• Synonyms: p107-
• Gene: Rbl1 Location: Chr2:156987813-157046454 bp, - strand Genetic Position: Chr2, 78.05 cM
• Alliance: Rbl1^tm1Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34058
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin cassette replaced sequences in exon 1 and a downstream intron of the Rbl1 gene. The authors predict that the mutant allele will synthesize only the first 22 amino acids of the wild-type protein. RBL1 protein was not detected in embryonic fibroblasts derived from homozygous mutant mice, or in homozygous mutant E18 embryos. Rbl1 transcript was not detected in homozygous mutant E18 embryos. (J:34058)

Disease models

Expression

In Mice Carrying this Mutation:	160 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rbl1^tm1Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbl1 Mutation: 60 strains or lines available

References

• Original: J:34058 Lee MH, et al., Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 1996 Jul 1;10(13):1621-32
• All: 62 reference(s)