Rbl2^tm1Tyj
Targeted Allele Detail

Summary

• Symbol: Rbl2^tm1Tyj
• Name: RB transcriptional corepressor like 2; targeted mutation 1, Tyler Jacks
• MGI ID: MGI:1857449
• Synonyms: p130-
• Gene: Rbl2 Location: Chr8:91796685-91850472 bp, + strand Genetic Position: Chr8, 44.25 cM
• Alliance: Rbl2^tm1Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34725
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequences in a proximal exon of the Rbl2 gene. Rbl2 mRNA levels in liver cells of homozygous mutant animals were reduced more than five fold compared to wild-type. Immunoblot analysis did not detect RBL2 protein in embryonic fibroblasts or in adult liver of homozygous mutant mice. (J:34725)

Disease models

Expression

In Mice Carrying this Mutation:

126 assay results

Tumor Data

List all tumor models in MMHCdb carrying Rbl2^tm1Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbl2 Mutation: 52 strains or lines available

References

• Original: J:34725 Cobrinik D, et al., Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996 Jul 1;10(13):1633-44
• All: 31 reference(s)