Sp4^tm1Ssp
Targeted Allele Detail

Summary

• Symbol: Sp4^tm1Ssp
• Name: trans-acting transcription factor 4; targeted mutation 1, S Steven Potter
• MGI ID: MGI:1857451
• Gene: Sp4 Location: Chr12:118198668-118265175 bp, - strand Genetic Position: Chr12, 63.48 cM
• Alliance: Sp4^tm1Ssp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33573
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding three zinc-finger domains was replaced with a construct containing an HPRT gene. Northern blot analysis of brain extracts showed the presence of an aberrant transcript in homozygous mutant mice. The transcript was undetectable in further analysis using a probe specific for the zinc-finger domains. (J:33573)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sp4 Mutation: 35 strains or lines available

References

• Original: J:33573 Supp DM, et al., Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev Biol. 1996 Jun 15;176(2):284-99
• All: 2 reference(s)