Vcam1^tm1Roml
Targeted Allele Detail

Summary

• Symbol: Vcam1^tm1Roml
• Name: vascular cell adhesion molecule 1; targeted mutation 1, Mark A Labow
• MGI ID: MGI:1857452
• Synonyms: VCAM-1 -
• Gene: Vcam1 Location: Chr3:115903669-115923337 bp, - strand Genetic Position: Chr3, 50.17 cM
• Alliance: Vcam1^tm1Roml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23137
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance expression cassette replaced a genomic fragment containing part of exon 2 and exons 3-5. These sequences encode the Ig domains. (J:23137)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vcam1 Mutation: 44 strains or lines available

References

• Original: J:23137 Kwee L, et al., Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development. 1995 Feb;121(2):489-503
• All: 3 reference(s)