Wnt4^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Wnt4^tm1Amc
• Name: wingless-type MMTV integration site family, member 4; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:1857453
• Synonyms: Wnt-4^-, Wnt4ⁿ
• Gene: Wnt4 Location: Chr4:137004946-137026812 bp, + strand Genetic Position: Chr4, 69.8 cM
• Alliance: Wnt4^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21884
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, encoding amino acids 106 through 196, was replaced by a PGK-neo cassette. The occasional expression of the targeted locus was observed in poorly developed aggregates in the kidneys of homozygous mutant mice via in situ hybridization. Expression was unaltered in the central nervous system and mesonephric mesenchyme. (J:21884)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	191 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Wnt4 Mutation: 21 strains or lines available

References

• Original: J:21884 Stark K, et al., Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature. 1994 Dec 15;372(6507):679-83
• All: 65 reference(s)