Srd5a1^tm1Mahe
Targeted Allele Detail

Summary

• Symbol: Srd5a1^tm1Mahe
• Name: steroid 5 alpha-reductase 1; targeted mutation 1, Mala Mahendroo
• MGI ID: MGI:1857454
• Synonyms: 5alphaRKO, Srd5a1^-
• Gene: Srd5a1 Location: Chr13:69721568-69759561 bp, - strand Genetic Position: Chr13, 35.55 cM
• Alliance: Srd5a1^tm1Mahe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32217
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region encompassing promoter region and the a 3' portion of exon 1, encoding thr first 36 amino acids, was replaced by a neomycin selection cassette. Northern blot analysis of total RNA isolated from several organs showed an absence of transcript in homozygous mutant mice. (J:32217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Srd5a1 Mutation: 11 strains or lines available

References

• Original: J:32217 Mahendroo MS, et al., 5 alpha-reduced androgens play a key role in murine parturition. Mol Endocrinol. 1996 Apr;10(4):380-92
• All: 20 reference(s)