Il2rg^tm1Wjl
Targeted Allele Detail

Summary

• Symbol: Il2rg^tm1Wjl
• Name: interleukin 2 receptor, gamma chain; targeted mutation 1, Warren J Leonard
• MGI ID: MGI:1857455
• Synonyms: CD132^-, gammac^-, gc^-, IL2Rgamma^null, Il2rg^tm1Wjll, [KO]gammac
• Gene: Il2rg Location: ChrX:100307991-100311861 bp, - strand Genetic Position: ChrX, 43.9 cM
• Alliance: Il2rg^tm1Wjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24117
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein. (J:24117)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Il2rg^tm1Wjl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 83 strains available Cell Lines: 0 lines available
• Carrying any Il2rg Mutation: 178 strains or lines available

References

• Original: J:24117 Cao X, et al., Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity. 1995 Mar;2(3):223-38
• All: 582 reference(s)