Ciita^tm1Ccum
Targeted Allele Detail

Summary

• Symbol: Ciita^tm1Ccum
• Name: class II transactivator; targeted mutation 1, Cheong-Hee Chang
• MGI ID: MGI:1857456
• Synonyms: C2ta^tm1Ccum, CIITA-, CIITA C^-, MHC classII^-
• Gene: Ciita Location: Chr16:10297923-10346282 bp, + strand Genetic Position: Chr16, 5.65 cM, cytoband B1
• Alliance: Ciita^tm1Ccum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31601
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons which encode critical regions of the protein was replaced with a neomycin selection gene. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:31601)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Ciita Mutation: 46 strains or lines available

References

• Original: J:31601 Chang CH, et al., Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity. 1996 Feb;4(2):167-78
• All: 67 reference(s)