Calb1^tm1Mpin
Targeted Allele Detail

Summary

• Symbol: Calb1^tm1Mpin
• Name: calbindin 1; targeted mutation 1, Max-Planck-Institute for Neurobiology
• MGI ID: MGI:1857460
• Synonyms: CaBP-, calbindin D28K -, Cb^-
• Gene: Calb1 Location: Chr4:15881264-15906709 bp, + strand Genetic Position: Chr4, 6.66 cM
• Alliance: Calb1^tm1Mpin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38599
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the promoter and first exon was replaced with a neomycin selection cassette. Western blot and immunohistochemistry analysis on tissues derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:38599)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Calb1 Mutation: 28 strains or lines available

References

• Original: J:38599 Airaksinen MS, et al., Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1488-93
• All: 38 reference(s)