Mdm2^tm1Bay
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm1Bay
• Name: transformed mouse 3T3 cell double minute 2; targeted mutation 1, Baylor College of Medicine
• MGI ID: MGI:1857463
• Synonyms: Mdm2^-, Mdm2^delta7-12, mdm2^ml
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm1Bay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29811
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An hprt reporter replaced a 7.1 kb fragment of the gene encompassing all of exons 7 through 11 and a portion of exon 12. The deleted region encoded all of the putative transcription function motifs of the protein. (J:29811, J:81065)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mdm2^tm1Bay

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 54 strains or lines available

References

• Original: J:29811 Jones SN, et al., Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature. 1995 Nov 9;378(6553):206-8
• All: 15 reference(s)