Ascl1^tm1And
Targeted Allele Detail

Summary

• Symbol: Ascl1^tm1And
• Name: achaete-scute family bHLH transcription factor 1; targeted mutation 1, David J Anderson
• MGI ID: MGI:1857470
• Synonyms: Ascl1^delta, Mash-1-, Mash1-, Mash-1^delta
• Gene: Ascl1 Location: Chr10:87326681-87329522 bp, - strand Genetic Position: Chr10, 43.64 cM
• Alliance: Ascl1^tm1And page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15850
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the entire coding region, 0.6 kb of sequence 5' of the translation initiation codon, and 0.2 kb of sequence 3' of the translation termination codon. (J:15850)

Expression

In Mice Carrying this Mutation:	546 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ascl1 Mutation: 28 strains or lines available

Notes

ES cell line = D3 (129S2/SvPas) or R1 (129S1/Sv x 129X1/SvJ)F1. The authors state that most phenotypic analysis was done on R1-derived mice.

References

• Original: J:15850 Guillemot F, et al., Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell. 1993 Nov 5;75(3):463-76
• All: 111 reference(s)