Ucp1^tm1Kz
Targeted Allele Detail

Summary

• Symbol: Ucp1^tm1Kz
• Name: uncoupling protein 1 (mitochondrial, proton carrier); targeted mutation 1, Leslie Kozak
• MGI ID: MGI:1857471
• Synonyms: Ucp1^-, Ucp^tm1
• Gene: Ucp1 Location: Chr8:84016981-84025081 bp, + strand Genetic Position: Chr8, 39.65 cM
• Alliance: Ucp1^tm1Kz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40053
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exon 2 and a portion of exon 3 were replaced by a neomycin selection cassette. The deleted region encoded an essential transmembrane domain. Transcript was undetected in homozygous mutant mice via Northern blot analysis. Western blot analysis confirmed the absence of encoded protein. (J:40053)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ucp1 Mutation: 51 strains or lines available

References

• Original: J:40053 Enerback S, et al., Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese [see comments]. Nature. 1997 May 1;387(6628):90-4
• All: 141 reference(s)