Cd1^tm1Gru
Targeted Allele Detail

Summary

• Symbol: Cd1^tm1Gru
• Name: CD1 antigen complex; targeted mutation 1, Michael Grusby
• MGI ID: MGI:1857482
• Synonyms: CD1^-, Cd1d^-, Cd1d1/Cd1d2^tm1Gru, CD1d KO, CD1tm1Gru
• Gene: Cd1 Location: unknown Genetic Position: Chr3, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47769
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Cd1^tm1Gru involves 2 genes/genome features (Cd1d2, Cd1d1) View all
• Mutation details: Both the Cd1d1 gene and the adjacent Cd1d2 gene were mutated in this allele. The coding sequence of Cd1d1 was replaced with a neomycin selection cassette and the coding sequence of Cd1d2 was deleted; however, the intergenic sequence was retained. Flow cytometric analysis on thymocytes derived from homozygous mice confirmed that no stable encoded protein was expressed on the cell surface. (J:47769)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cd1^tm1Gru

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Cd1 Mutation: 7 strains or lines available

References

• Original: J:47769 Smiley ST, et al., Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 1997 Feb 14;275(5302):977-9
• All: 124 reference(s)