Mef2c^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Mef2c^tm1Eno
• Name: myocyte enhancer factor 2C; targeted mutation 1, Eric N Olson
• MGI ID: MGI:1857491
• Synonyms: Mef2c^delta2, Mef2c^KO, MEF2C null, mef2c^tm1
• Gene: Mef2c Location: Chr13:83652153-83815199 bp, + strand Genetic Position: Chr13, 43.68 cM
• Alliance: Mef2c^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40724
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exon 2, encoding amino acids 18-86, with a neomycin cassette. (J:40724)

Expression

In Mice Carrying this Mutation:	149 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	31 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mef2c Mutation: 34 strains or lines available

References

• Original: J:40724 Lin Q, et al., Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 1997 May 30;276(5317):1404-7
• All: 32 reference(s)