Hmx3^tm1Ebo
Targeted Allele Detail

Summary

• Symbol: Hmx3^tm1Ebo
• Name: H6 homeobox 3; targeted mutation 1, Eva Bober
• MGI ID: MGI:1857493
• Synonyms: Nkx5-1^-
• Gene: Hmx3 Location: Chr7:131144596-131146654 bp, + strand Genetic Position: Chr7, 74.32 cM
• Alliance: Hmx3^tm1Ebo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45576
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced all of exon 1 and part of exon 2, including the N-terminal one-third of the homeobox DNA-binding domain. No transcripts were detectable by in situ hybridization in homozygous mutant mice. (J:45576)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hmx3 Mutation: 17 strains or lines available

References

• Original: J:45576 Hadrys T, et al., Nkx5-1 controls semicircular canal formation in the mouse inner ear. Development. 1998 Jan;125(1):33-9
• All: 4 reference(s)