Nkx2-1^tm1Shk
Targeted Allele Detail

Summary

• Symbol: Nkx2-1^tm1Shk
• Name: NK2 homeobox 1; targeted mutation 1, Shioko Kimura
• MGI ID: MGI:1857494
• Synonyms: Nkx2.1-, T/EBP/NKX2.1-null, T/ebp null, Titf1-
• Gene: Nkx2-1 Location: Chr12:56578741-56583570 bp, - strand Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
• Alliance: Nkx2-1^tm1Shk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30559
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into the second exon of the gene disrupted the first helix of the homeo domain sequence. (J:30559)

Expression

In Mice Carrying this Mutation:	196 assay results
In Structures Affected by this Mutation:	24 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nkx2-1 Mutation: 24 strains or lines available

References

• Original: J:30559 Kimura S, et al., The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 1996 Jan 1;10(1):60-9
• All: 48 reference(s)