Gsc^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Gsc^tm1Pgr
• Name: goosecoid homeobox; targeted mutation 1, Peter Gruss
• MGI ID: MGI:1857496
• Gene: Gsc Location: Chr12:104437468-104439495 bp, - strand Genetic Position: Chr12, 54.32 cM
• Alliance: Gsc^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29421
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into exon 2, disrupting sequences encoding the homeodomain. (J:29421)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	29 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gsc Mutation: 15 strains or lines available

References

• Original: J:29421 Yamada G, et al., Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death. Development. 1995 Sep;121(9):2917-22
• All: 7 reference(s)