Gja8^No2
Chemically induced Allele Detail

Summary

• Symbol: Gja8^No2
• Name: gap junction protein, alpha 8; nuclear opacity 2
• MGI ID: MGI:1857499
• Synonyms: Cx50D47A, ENU-326, No2
• Gene: Gja8 Location: Chr3:96820882-96833336 bp, - strand
• Alliance: Gja8^No2 page

Mutation origin

• Strain of Origin: (101 x C3H)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A-to-C transversion in the coding region mutated codon 47. This results in the nonconservative substitution of alanine for aspartic acid in a highly conserved region of the first extracellular loop of the peptide. (J:49492)
• Inheritance: Semidominant

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gja8 Mutation: 33 strains or lines available

References

• Original: J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
• All: 9 reference(s)