Rbl2^tm1Mru
Targeted Allele Detail

Summary

• Symbol: Rbl2^tm1Mru
• Name: RB transcriptional corepressor like 2; targeted mutation 1, Michael Rudnicki
• MGI ID: MGI:1857500
• Synonyms: p130-
• Gene: Rbl2 Location: Chr8:91796685-91850472 bp, + strand Genetic Position: Chr8, 44.25 cM
• Alliance: Rbl2^tm1Mru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50516
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a PGK neomycin resistance cassette into an exon disrupted the Rbl2 gene. Northern analysis of homozygous mutant embryos (E14) using a full length Rbl2 cDNA probe did not detect Rbl2 mRNA. Immunoblot analysis using antisera reactive with the carboxyl-terminal 20 amino acids of RBL2 did not detect RBL2 in homozygous mutant embryos. (J:50516)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbl2 Mutation: 52 strains or lines available

References

• Original: J:50516 LeCouter JE, et al., Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene. Development. 1998 Dec;125(23):4669-79
• All: 2 reference(s)