Otx2^tm1Sla
Targeted Allele Detail

Summary

• Symbol: Otx2^tm1Sla
• Name: orthodenticle homeobox 2; targeted mutation 1, Siew Lan Ang
• MGI ID: MGI:1857502
• Synonyms: Otx2-, Otx2^hd, Otx2^neo
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm1Sla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30828
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the sequences encoding the homeodomain. This mutation is predicted to truncate the Otx2 coding sequence immediately after the first 32 amino acids. (J:30828)

Expression

In Mice Carrying this Mutation:	83 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:30828 Ang SL, et al., A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development. 1996 Jan;122(1):243-52
• All: 8 reference(s)