Hoxa1^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Hoxa1^tm1Ipc
• Name: homeobox A1; targeted mutation 1, Pierre Chambon
• MGI ID: MGI:1857504
• Synonyms: Hox-1.6-, Hoxa1^null, Hoxa-1^tot
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^tm1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23837
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of nucleotides -49 to +373 relative to the transcription initiation site with a neomycin cassette. (J:23837)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	366 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	35 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

References

• Original: J:23837 Lufkin T, et al., Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell. 1991 Sep 20;66(6):1105-19
• All: 16 reference(s)