Gli2^tm1Alj
Targeted Allele Detail

Summary

• Symbol: Gli2^tm1Alj
• Name: GLI-Kruppel family member GLI2; targeted mutation 1, Alexandra L Joyner
• MGI ID: MGI:1857509
• Synonyms: Gli2^-, Gli2^zfd
• Gene: Gli2 Location: Chr1:118761862-118981349 bp, - strand Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
• Alliance: Gli2^tm1Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38381
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 2.4 kb of the gene, resulting in the deletion of exons that encode the zinc fingers 3 - 5 of the protein and 71 amino acid residues carboxyl to these zinc fingers. (J:38381, J:49164)

Expression

In Mice Carrying this Mutation:	646 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	52 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli2 Mutation: 169 strains or lines available

References

• Original: J:38381 Mo R, et al., Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development. 1997 Jan;124(1):113-23
• All: 119 reference(s)