Otx2^tm1Pas
Targeted Allele Detail

Summary

• Symbol: Otx2^tm1Pas
• Name: orthodenticle homeobox 2; targeted mutation 1, Institut Pasteur
• MGI ID: MGI:1857510
• Synonyms: Otx2^-, Otx2^lacZ
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm1Pas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29276
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene and neomycin cassette were inserted in-frame into the gene at a position 213 nucleotides upstream of the translation initiation site. A beta-galactosidase protein is expressed from this allele under the control of the endogenous promoter. (J:29276)

Expression

In Mice Carrying this Mutation:	234 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:29276 Acampora D, et al., Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90
• All: 12 reference(s)