Rxra^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Rxra^tm1Ipc
• Name: retinoid X receptor alpha; targeted mutation 1, Pierre Chambon
• MGI ID: MGI:1857511
• Synonyms: Rxr alpha AF2^I, Rxralpha^af2(l), Rxr alpha AF2^O
• Gene: Rxra Location: Chr2:27566452-27652969 bp, + strand Genetic Position: Chr2, 19.38 cM
• Alliance: Rxra^tm1Ipc page

Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50515
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: This allele encodes a protein that lacks the final 18 amino acids (position 450 to 467) due to a nonsense mutation introduced into exon 10. The deletion corresponds to the last alpha helical structure (helix 12) of the ligand binding domain. A floxed neo cassette was inserted into intron 9 for selection. (J:50515)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxra Mutation: 30 strains or lines available

References

• Original: J:50515 Mascrez B, et al., The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development. Development. 1998 Dec;125(23):4691-707
• All: 14 reference(s)