Otx2^tm2Sla
Targeted Allele Detail

Summary

• Symbol: Otx2^tm2Sla
• Name: orthodenticle homeobox 2; targeted mutation 2, Siew Lan Ang
• MGI ID: MGI:1857513
• Synonyms: Otx2^hygro
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm2Sla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46641
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin resistance cassette replaced the first and second exons of the gene, including the translation start site and and most of the sequences encoding the homeodomain. (J:46641)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:46641 Rhinn M, et al., Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development. 1998 Mar;125(5):845-56
• All: 2 reference(s)