Tlx2^tm1Ut
Targeted Allele Detail

Summary

• Symbol: Tlx2^tm1Ut
• Name: T cell leukemia, homeobox 2; targeted mutation 1, University of Toronto
• MGI ID: MGI:1857514
• Synonyms: Tlx-2^-
• Gene: Tlx2 Location: Chr6:83045306-83047206 bp, - strand Genetic Position: Chr6, 35.94 cM, cytoband C3-D1
• Alliance: Tlx2^tm1Ut page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48372
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ sequence and neomycin resistance cassette replaced most of the first exon, starting at the initiation codon. (J:48372)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlx2 Mutation: 12 strains or lines available

References

• Original: J:48372 Tang SJ, et al., The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development. 1998 May;125(10):1877-87
• All: 1 reference(s)