Cripto^tm1Eda
Targeted Allele Detail

Summary

• Symbol: Cripto^tm1Eda
• Name: cripto, EGF-CFC family member; targeted mutation 1, Eileen D Adamson
• MGI ID: MGI:1857518
• Synonyms: Cr1-, cripto-
• Gene: Cripto Location: Chr9:110768676-110775226 bp, - strand Genetic Position: Chr9, 60.79 cM
• Alliance: Cripto^tm1Eda page

Gastrulation defects in Cripto^tm1.1Gmin and Cripto^tm1Eda homozygous embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51595
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced exons 3-5 via homologous recombination. PCR and Southern blot confirmed recombination in ES cells. These cells were used to create a second knockout. (J:47293)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	110 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cripto Mutation: 55 strains or lines available

References

• Original: J:51595 Xu C, et al., Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development. 1999 Feb;126(3):483-94
• All: 8 reference(s)