Ngf^tm1Gne
Targeted Allele Detail

Summary

• Symbol: Ngf^tm1Gne
• Name: nerve growth factor; targeted mutation 1, Genentech
• MGI ID: MGI:1857535
• Synonyms: NGF-, Ngfb^tm1
• Gene: Ngf Location: Chr3:102377235-102428329 bp, + strand Genetic Position: Chr3, 45.25 cM
• Alliance: Ngf^tm1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17792
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of a 150 bp fragment of the Ngfb gene, including the exon IV splice acceptor site and 130-bp of NGF coding sequence including the translation start site, with a CMV-neomycin cassette. (J:17792)

Expression

In Mice Carrying this Mutation:	58 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ngf Mutation: 12 strains or lines available

References

• Original: J:17792 Crowley C, et al., Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell. 1994 Mar 25;76(6):1001-11
• All: 37 reference(s)