Map2k4^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Map2k4^tm1Pngr
• Name: mitogen-activated protein kinase kinase 4; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:1857536
• Synonyms: Epha4^tm1Oci, Sek1 -
• Gene: Map2k4 Location: Chr11:65579069-65679123 bp, - strand Genetic Position: Chr11, 40.53 cM
• Alliance: Map2k4^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77942
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette. Neither transcript nor protein was detected in homozygous mutant ES cells. (J:77942)

Expression

In Mice Carrying this Mutation:

16 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map2k4 Mutation: 33 strains or lines available

References

• Original: J:77942 Nishina H, et al., Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature. 1997 Jan 23;385(6614):350-3
• All: 7 reference(s)