Wld^s
Spontaneous Allele Detail

Summary

• Symbol: Wld^s
• Name: wallerian degeneration; Wallerian degeneration slow
• MGI ID: MGI:1857538
• Synonyms: Wlds
• Gene: Wld Location: Chr4:149260776-149632709 bp Genetic Position: Chr4, Syntenic
• Alliance: Wld^s page

Mutation origin

• Strain of Origin: C57BL/6Ola

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Wld^s involves 3 genes/genome features (Ube4b, Rbp7, Nmnat1) View all
• Mutation details: The underlying mutation is an 85-kb tandem triplication on chromosome 4. This triplication results in the expression of an abnormal transcript that encodes a fusion of the N-terminal fragment of ubiquitination factor E4B (Ube4b) fused to nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1). (J:49401, J:65178, J:72936, J:75678)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wld Mutation: 2 strains or lines available

References

• Original: J:15229 Lyon MF, et al., A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9717-20
• All: 124 reference(s)