Jup^tm1Kem
Targeted Allele Detail

Summary

• Symbol: Jup^tm1Kem
• Name: junction plakoglobin; targeted mutation 1, Rolf Kemler
• MGI ID: MGI:1857539
• Synonyms: Pg-, plako-
• Gene: Jup Location: Chr11:100259784-100288589 bp, - strand Genetic Position: Chr11, 63.47 cM
• Alliance: Jup^tm1Kem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38047
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exons 3 and 4 of the gene. (J:38047)

Disease models

Expression

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jup Mutation: 162 strains or lines available

References

• Original: J:38047 Bierkamp C, et al., Embryonic heart and skin defects in mice lacking plakoglobin. Dev Biol. 1996 Dec 15;180(2):780-5
• All: 7 reference(s)