Otx2^tm1Sia
Targeted Allele Detail

Summary

• Symbol: Otx2^tm1Sia
• Name: orthodenticle homeobox 2; targeted mutation 1, Shinichi Aizawa
• MGI ID: MGI:1857543
• Synonyms: Otx2^-
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29682
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into sequences encoding the homeobox domain. (J:29682, J:74631)

Expression

In Mice Carrying this Mutation:	220 assay results
In Structures Affected by this Mutation:	51 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:29682 Matsuo I, et al., Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 1995 Nov 1;9(21):2646-58
• All: 17 reference(s)