Kras^tm1Mok
Targeted Allele Detail

Summary

• Symbol: Kras^tm1Mok
• Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Motoya Katsuki
• MGI ID: MGI:1857551
• Synonyms: K-ras^-
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^tm1Mok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42943
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaces the 3' part of exon 1, which encodes a part of the effector domain essential for K-ras activity. (J:42943)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 84 strains or lines available

References

• Original: J:42943 Koera K, et al., K-ras is essential for the development of the mouse embryo. Oncogene. 1997 Sep 4;15(10):1151-9
• All: 3 reference(s)