Alx1^tm1Crm
Targeted Allele Detail

Summary

• Symbol: Alx1^tm1Crm
• Name: ALX homeobox 1; targeted mutation 1, Benoit de Crombrugghe
• MGI ID: MGI:1857553
• Synonyms: Cart1^-
• Gene: Alx1 Location: Chr10:102834564-102865501 bp, - strand Genetic Position: Chr10, 53.56 cM
• Alliance: Alx1^tm1Crm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33716
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 7.4kb genomic fragment containing exons 1-3. These sequences encode two thirds of the protein including the homeodomain and the potential translation initiation site. (J:33716)

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alx1 Mutation: 22 strains or lines available

References

• Original: J:33716 Zhao Q, et al., Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene. Nat Genet. 1996 Jul;13(3):275-83
• All: 4 reference(s)