Zfpm1^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Zfpm1^tm1Sho
• Name: zinc finger protein, multitype 1; targeted mutation 1, Stuart Orkin
• MGI ID: MGI:1857554
• Synonyms: FOG-1^-
• Gene: Zfpm1 Location: Chr8:123008880-123063990 bp, + strand Genetic Position: Chr8, 70.86 cM, cytoband E1
• Alliance: Zfpm1^tm1Sho page

Cardiac defects in Zfpm1^tm1Sho/Zfpm1^tm1Sho Tg(Gata1-Zfpm1)1Sho mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47281
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the first 7 of 9 zinc finger domains was deleted by the insertion of a neomycin selection cassette. (J:47281)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfpm1 Mutation: 33 strains or lines available

References

• Original: J:47281 Tsang AP, et al., Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 1998 Apr 15;12(8):1176-88
• All: 4 reference(s)