Klf1^tm1Nimr
Targeted Allele Detail

Summary

• Symbol: Klf1^tm1Nimr
• Name: Kruppel-like transcription factor 1 (erythroid); targeted mutation 1, National Institute of Medical Research
• MGI ID: MGI:1857557
• Synonyms: EKLF^-
• Gene: Klf1 Location: Chr8:85628611-85631920 bp, + strand Genetic Position: Chr8, 41.3 cM
• Alliance: Klf1^tm1Nimr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25650
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A LacZ gene and neomycin resistance cassette was inserted in-frame into the genomic sequence just after the initiator ATG codon. This allele expresses beta-galactosidase under the control of the endogenous promoter. (J:25650)

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf1 Mutation: 22 strains or lines available

References

• Original: J:25650 Nuez B, et al., Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature. 1995 May 25;375(6529):316-8
• All: 10 reference(s)